Nicotinamide mononucleotide, NMN, is a molecule that has been identified as a key factor in reversing the effects of aging in mouse stem cells. The NMN molecule increases NAD+, which is related to human metabolism and cellular energy. The researchers found that by supplementing the mice with NMN, they were able to reverse some of the effects of cellular aging seen in these mice. After six weeks, the researchers saw an increase in the number of blood vessels and an improvement in mitochondrial function in both liver and muscle tissue and found that it might be possible to rebuild muscle mass. NMN improves cognitive function and increases endurance. It is used to treat angiogenesis (growth of new blood vessels)
NAD or nicotinamide adenine dinucleotide is a derivative of Vitamin B3 also known as niacin, niacinamide or nicotinamide (soluble form). NAD is used in more than 500 reactions, it has a crucial role in metabolism, cell aging, DNA repair, and gene expression.
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Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).